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Supporting Protocol: Preparation of Hybrid TissueSpec® ECM Hydrogel and Collagen Type I Hydrogel


Service Data Sheet: IN MATRICO® Lung Fibrosis Assays – Protein Secretion


Webinar: Targeting Tumor Metabolic Adaptations in The Metastatic Niche to Improve Therapy Efficacy

In this webinar, we discuss how the IN SITE™ Metastasis Kit can enable researchers to model common metastatic microenvironments. Dr. Evelyn Aranda and Dr. Zeynep Madak-Erdogan discuss how to evaluate anti-cancer therapeutics in physiologically-relevant tumor models, to investigate metabolic changes in hormone-positive breast cancer, and to identify mechanisms of tumor drug resistance. (more…)



Publication: Targeting Metabolic Adaptations in The Breast Cancer-Liver Metastatic Niche Using Dietary Approaches to Improve Endocrine Therapy Efficacy (2022)

Most patients with ER+ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant (Fulv) as standard-of-care. Yet, among such patients, metastasis in the liver is associated with reduced overall survival compared to other metastasis sites. The factors underlying the reduced responsiveness of liver metastases to ER-targeting agents remain unknown, impeding the development of more effective treatment approaches to improve outcomes for patients with ER+ liver metastases. The objective of this study was to identify how the metabolism–cancer nexus in liver affects the response of metastatic ER+ tumors to Fulv, focusing particularly on tumor-intrinsic metabolic mechanisms arising following Fulv exposure.


Product Data Sheet: TissueSpec® Heart ECM Hydrogel Kit


Service Data Sheet: IN MATRICO® Liver Fibrosis Assays


Service Data Sheet: IN MATRICO® Lung Fibrosis Assays


Instructions for Use: IN SITE™ Metastasis Surface Coating Kit


Instructions for Use: IN SITE™ Metastasis Hydrogel Kit


Product Data Sheet: TissueSpec® Skin ECM Hydrogel Kit


Product Data Sheet: TissueSpec® Bone ECM Hydrogel Kit


Instructions for Use: TissueSpec® ECM Hydrogel Kit


Instructions for Use: NativeCoat™ ECM Surface Coating Kit


Supporting Protocol: Migration Assay with TissueSpec® ECM Hydrogel Kit


Supporting Protocol: Invasion Assay with TissueSpec® ECM Hydrogel Kit


Webinar: Transforming Lung Fibrosis Drug Discovery with The IN MATRICO® Human Lung Fibrosis Platform

Lung extracellular matrix (ECM) is implicated in the pathogenesis and progression of lung fibrosis. Current preclinical lung fibrosis models do not incorporate lung ECM, and therefore lack the defining part of the fibrotic lung disease environment. In this webinar, we describe the paradigm shift in drug discovery from ‘in vitro’ to ‘in matrico’, and present our Human Lung Fibrosis platform for disease modeling and compound testing. Leveraging human fibrotic lung ECM and corresponding clinical data, the platform increases the relevance of cell-based assays and enables lung fibrosis modeling with clinical context to accelerate drug development.



Publication: Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers (2020)

The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ERtumors. The objective of this study was to elucidate the role of metabolic pathways that undermine therapy efficacy in ERbreast cancers.


Webinar: Redefining Cancer Research with IN SITE™ Metastasis Kit

In this webinar we present the IN SITE™ Metastasis Kit, which contains tissue-specific bone, liver, and lung ECMs, as an in-vitro tool that enables physiologically-relevant studies of metastasis as well as accelerates drug development efforts.



Application Note: IN SITE™ Metastasis Kit to Accelerate Anticancer Drug Development

IN SITE™ Metastasis Kit contains bone, liver, and lung ECMs with tissue-specific compositions and mechanics to model colonization of tumor cells in common secondary sites. Recapitulation of site specific microenvironments is key to identify drivers of metastasis and targets for therapeutic intervention.


Poster: TissueSpec® Bone, Liver, and Lung ECM Substrates Enable Disease-Relevant in-vitro Models of Pre-Metastatic Tissue Microenvironments


Publication: Fibrotic Human Lung Extracellular Matrix as a Disease-Specific Substrate for Models of Pulmonary Fibrosis (2019)

Idiopathic Pulmonary Fibrosis (IPF) is an irreversible and uniformly fatal lung disease marked by destruction and scarring of the lung parenchyma and progressive loss of respiratory function. Unfortunately, predictive models of IPF are not available, underscoring the critical need for physiologically relevant in-vitro substrates that enable quantitative and mechanistic studies of human IPF. Here we report the development and characterization of a human pulmonary fibrosis specific cell culture substrate comprised of intact fibrotic lung extracellular matrix that recapitulates the human IPF disease environment in vitro. Altogether, our results demonstrate the applicability of this fibrosis-specific substrate for 3D in-vitro models of IPF and cell-based assays in early-stage drug discovery.


White Paper: 3D Lung Tumor Model with Lung Extracellular Matrix to Predict Drug Efficacy


Poster: Fibrotic Liver Extracellular Matrix Substrates for 3D in-vitro Models of Human Liver Fibrosis


Application Note: Accelerating Antifibrotic Drug Development with Human Fibrotic Liver ECM Substrates


Poster: Fibrotic Lung Extracellular Matrix Substrates for 3D in-vitro Models of Human Pulmonary Fibrosis


Application Note: Accelerating Antifibrotic Drug Development with Human Fibrotic Lung ECM Substrates


Poster: TissueSpec® ECM Hydrogels for Predictive 3D Models of Human Cancer


Product Data Sheet: TissueSpec® Intestine ECM Hydrogel Kit


Supporting Protocol: TissueSpec® ECM Hydrogel Kit – Preparation for Immunostaining


Supporting Protocol: TissueSpec® ECM Hydrogel Kit – Dissociation for Cell Isolation and Analysis


Publication: Functional Vascularized Lung Grafts for Lung Bioengineering (2017)


Publication: Chondrogenic Properties of Collagen Type XI, a Component of Cartilage Extracellular Matrix (2018)


Publication: Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability (2017)


Publication: Bioengineered Models of Solid Human Tumors for Cancer Research (2016)


Publication: Tissue Engineered Autologous Grafts for Facial Bone Reconstruction (2016)


Publication: Efficient Generation of Lung and Airway Epithelial Cells from Human Pluripotent Stem Cells (2014)


Publication: The Regulation of Growth and Metabolism of Kidney Stem Cells with Regional Specificity Using Extracellular Matrix Derived from Kidney (2013)


Publication: Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering (2013)


Publication: Engineering Bone Tissue from Human Embryonic Stem Cells (2012)


Publication: Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors (2011)


Publication: Composite Scaffold Provides a Cell Delivery Platform for Cardiovascular Repair (2011)


Product Data Sheet: Custom TissueSpec® ECM Scaffold


Product Data Sheet: TissueSpec® Lung ECM Hydrogel Kit


Product Data Sheet: TissueSpec® Liver ECM Hydrogel Kit


Product Data Sheet: NativeCoat™ ECM Surface Coating Kit


Video: Tissue-Specific Cell Culture Substrates

Learn more about our tissue-specific cell culture substrates and their application in 3D cell culture.



Poster: TissueSpec® Extracellular Matrix Substrates for 3D Cell Culture