TissueSpec® Bone, Liver, and Lung ECM substrates enable disease-relevant in-vitro models of pre-metastatic tissue microenvironments.

E. Aranda¹, E. Gadee¹, I. Germanguz¹, J.C. Xiong¹, N. Kissel¹, A. Nichols¹, D.P. Daly¹, D. Shvartsman², D. Deems², J.D. O’Neill1* ¹ Xylyx Bio, Brooklyn, New York, USA ² Cellaria, Wakefield, Massachusetts, USA

Current in-vitro models of metastasis fail to recapitulate the critical cell–matrix interactions involving the pre-metastatic extracellular matrix (ECM) of liver, lung, and bone tissues. Tissue-specific ECM substrates have biochemical and mechanical features that enable disease-relevant in-vitro modeling of metastatic processes in bone, liver, and lung tissue microenvironments and are compatible with 3D applications and assays.