What we do
Xylyx harnesses the power of extracellular matrix (ECM) – the body’s natural essential cellular microenvironment – to create biomaterials that provide cells with complex structural support and biochemical signals required for cellular function. Xylyx biomaterials comprise both the mechanical properties and complex ratios of the cellular environment specific and unique to organ type and disease state, enabling drug candidates to be investigated in vitro in a human-relevant environment. By recapitulating the defining physiological feature of human disease, Xylyx Bio’s In Matrico™ Platform brings much-needed insight into the efficacy of candidate compounds consistent with clinical results.
Why is extracellular matrix important?
Extracellular matrix provides shape, integrity and motion for all multicellular living organisms, and is essential for cell function and regeneration. ECM is indispensable for both embryonic development and tissue remodeling in the adult. “Without ECM, multicellular life could not exist, plants would not grow tall, and animals could neither swim nor walk nor fly.” WH Lewis
Competing systems are not physiologic and thus non-predictive, failing to recapitulate human disease and contributing to high cost and late stage failures in drug discovery. Existing products derive from a single component (e.g., collagen I) or rodent extracts (e.g. Matrigel, etc.). Lack of key physiologic benefits hinders predictive value, a major shortcoming that costs pharma time and money in the quest for effective drug candidates. In contrast, Xylyx products bring critical value to drug development efforts by supporting pharma in frontloading attrition earlier in the discovery process and thus reducing substantial costs associated with late-stage attrition due to poor efficacy and toxicity.